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Sensors 2014, 14(11), 21375-21384; doi:10.3390/s141121375

Synthesis of a Cu2+-Selective Probe Derived from Rhodamine and Its Application in Cell Imaging

Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou 571199, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 15 August 2014 / Revised: 4 November 2014 / Accepted: 5 November 2014 / Published: 12 November 2014
(This article belongs to the Special Issue Molecular Sensing and Molecular Electronics)
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Abstract

A new fluorescent probe P based on rhodamine for Cu2+ was synthesized and characterized. The new probe P showed high selectivity to Cu2+ over other tested metal ions. With optimal conditions, the proposed probe P worked in a wide linear range of 1.0 × 106–1.0 × 105 M with a detection limit of 3.3 × 10−7 M Cu2+ in ethanol-water solution (9:1, v:v, 20 mM HEPES, pH 7.0). Furthermore, it has been used for imaging of Cu2+ in living cells with satisfying results. View Full-Text
Keywords: rhodamine derivative; fluorescence enhancement; fluorescence imaging rhodamine derivative; fluorescence enhancement; fluorescence imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yu, C.; Wen, Y.; Zhang, J. Synthesis of a Cu2+-Selective Probe Derived from Rhodamine and Its Application in Cell Imaging. Sensors 2014, 14, 21375-21384.

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