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Sensors 2014, 14(10), 18941-18959; doi:10.3390/s141018941

Monitoring Key Parameters in Bioprocesses Using Near-Infrared Technology

Department of Life Science and Biotecnology, University of Ferrara, Via L. Borsari, 46 I-44121, Italy
Author to whom correspondence should be addressed.
Received: 1 September 2014 / Revised: 19 September 2014 / Accepted: 25 September 2014 / Published: 13 October 2014
(This article belongs to the Special Issue Sensors for Bioprocess Monitoring and Control)
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Near-infrared spectroscopy (NIRS) is known to be a rapid and non-destructive technique for process monitoring. Bioprocesses are usually complex, from both the chemical (ill-defined medium composition) and physical (multiphase matrix) aspects, which poses an additional challenge to the development of robust calibrations. We investigated the use of NIRS for on-line and in-line monitoring of cell, substrate and product concentrations, during aerobic and anaerobic bacterial fermentations, in different fermentation strategies. Calibration models were built up, then validated and used for the automated control of fermentation processes. The capability of NIR in-line to discriminate among differently shaped bacteria was tested. View Full-Text
Keywords: near-infrared spectroscopy; fermentation; on-line monitoring; in-line monitoring; calibration curves; bioprocess control near-infrared spectroscopy; fermentation; on-line monitoring; in-line monitoring; calibration curves; bioprocess control

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tamburini, E.; Marchetti, M.G.; Pedrini, P. Monitoring Key Parameters in Bioprocesses Using Near-Infrared Technology. Sensors 2014, 14, 18941-18959.

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