Next Article in Journal
CO Responses of Sensors Based on Cerium Oxide Thick Films Prepared from Clustered Spherical Nanoparticles
Next Article in Special Issue
Reconfigurable, Defect-Free, Ultrahigh-Q Photonic Crystal Microcavities for Sensing
Previous Article in Journal / Special Issue
Design Optimization of Structural Parameters for Highly Sensitive Photonic Crystal Label-Free Biosensors
Sensors 2013, 13(3), 3242-3251; doi:10.3390/s130303242

Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

1 DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800 Kgs. Lyngby, Denmark 2 DAKO Denmark A/S, Produktionsvej 42, DK-2600 Glostrup, Denmark 3 Bioneer A/S, Kogle Allé 2, 2970 Hørsholm, Denmark Present address: PCMA Rus, Kaluga Region, Russia.
* Author to whom correspondence should be addressed.
Received: 17 January 2013 / Revised: 22 February 2013 / Accepted: 6 March 2013 / Published: 8 March 2013
(This article belongs to the Special Issue Photonic Crystal Sensors)
View Full-Text   |   Download PDF [449 KB, uploaded 21 June 2014]   |   Browse Figures


We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.
Keywords: microstructured polymer optical fiber; fluorescence; antibodies microstructured polymer optical fiber; fluorescence; antibodies
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Emiliyanov, G.; Høiby, P.E.; Pedersen, L.H.; Bang, O. Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers. Sensors 2013, 13, 3242-3251.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert