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Sensors 2013, 13(3), 3242-3251; doi:10.3390/s130303242
Article

Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

1,†
, 2
, 3
 and 1,*
Received: 17 January 2013; in revised form: 22 February 2013 / Accepted: 6 March 2013 / Published: 8 March 2013
(This article belongs to the Special Issue Photonic Crystal Sensors)
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Abstract: We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.
Keywords: microstructured polymer optical fiber; fluorescence; antibodies microstructured polymer optical fiber; fluorescence; antibodies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Emiliyanov, G.; Høiby, P.E.; Pedersen, L.H.; Bang, O. Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers. Sensors 2013, 13, 3242-3251.

AMA Style

Emiliyanov G, Høiby PE, Pedersen LH, Bang O. Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers. Sensors. 2013; 13(3):3242-3251.

Chicago/Turabian Style

Emiliyanov, Grigoriy; Høiby, Poul E.; Pedersen, Lars H.; Bang, Ole. 2013. "Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers." Sensors 13, no. 3: 3242-3251.



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