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Sensors 2013, 13(12), 16672-16681; doi:10.3390/s131216672

Fabrication of a Microneedle/CNT Hierarchical Micro/Nano Surface Electrochemical Sensor and Its In-Vitro Glucose Sensing Characterization

Department of Electrical Engineering, the University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX 75080, USA
Department of Information and Communication Engineering, Hanbat National University, 125 Dongseodaero, Yuseong-Gu, Daejeon 305-719, Korea
Author to whom correspondence should be addressed.
Received: 18 October 2013 / Revised: 14 November 2013 / Accepted: 22 November 2013 / Published: 4 December 2013
(This article belongs to the Section Chemical Sensors)
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We report fabrication of a microneedle-based three-electrode integrated electrochemical sensor and in-vitro characterization of this sensor for glucose sensing applications. A piece of silicon was sequentially dry and wet etched to form a 15 × 15 array of tall (approximately 380 µm) sharp silicon microneedles. Iron catalyst was deposited through a SU-8 shadow mask to form the working electrode and counter electrode. A multi-walled carbon nanotube forest was grown directly on the silicon microneedle array and platinum nano-particles were electrodeposited. Silver was deposited on the Si microneedle array through another shadow mask and chlorinated to form a Ag/AgCl reference electrode. The 3-electrode electrochemical sensor was tested for various glucose concentrations in the range of 3~20 mM in 0.01 M phosphate buffered saline (PBS) solution. The sensor’s amperometric response to the glucose concentration is linear and its sensitivity was found to be 17.73 ± 3 μA/mM-cm2. This microneedle-based sensor has a potential to be used for painless diabetes testing applications.
Keywords: microneedle; glucose sensing; nanoparticle microneedle; glucose sensing; nanoparticle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yoon, Y.; Lee, G.S.; Yoo, K.; Lee, J.-B. Fabrication of a Microneedle/CNT Hierarchical Micro/Nano Surface Electrochemical Sensor and Its In-Vitro Glucose Sensing Characterization. Sensors 2013, 13, 16672-16681.

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