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Sensors 2013, 13(10), 14029-14040; doi:10.3390/s131014029
Article

Simultaneous Determination of Dopamine, Serotonin and Ascorbic Acid at a Glassy Carbon Electrode Modified with Carbon-Spheres

1,2
,
1
,
1,3
,
1,4
 and
1,*
1 Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB), Key Laboratory of Chemo/Biosensing, Anhui Province, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China, 2 Department of Pharmacy, Anhui Medical College, Hefei 230601, China 3 College of Chemistry and Chemical Engineering, Fuyang Teachers College, Fuyang 236041, China 4 Department of Chemistry and Food Science, Chizhou College, Chizhou 247000, China
* Author to whom correspondence should be addressed.
Received: 7 September 2013 / Revised: 6 October 2013 / Accepted: 12 October 2013 / Published: 16 October 2013
(This article belongs to the Section Chemical Sensors)
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Abstract

A novel glassy carbon electrode (GCE) modified with carbon-spheres has been fabricated through a simple casting procedure. The modified GCE displays high selectivity and excellent electrochemical catalytic activities towards dopamine (DA), serotonin (5-HT), and ascorbic acid (AA). In the co-existence system, the peak separations between AA and DA, DA and 5-HT, and AA and 5-HT are large up to 230, 180, and 410 mV, respectively. Differential pulse voltammetry (DPV) has been employed to simultaneously detect DA, 5-HT, and AA, and the linear calibration curves for DA, 5-HT, and AA are obtained in the range of 20.0–150.0 μM, 40.0–750.0 μM and 300.0–2,000.0 μM with detection limits (S/N = 3) of 2.0 μM, 0.7 μM and 0.6 μM, respectively. The proposed electrode has been applied to detect DA, 5-HT, and AA in real samples using standard addition method with satisfactory results.
Keywords: carbon-spheres; simultaneous determination; dopamine; ascorbic acid; serotonin carbon-spheres; simultaneous determination; dopamine; ascorbic acid; serotonin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhou, J.; Sheng, M.; Jiang, X.; Wu, G.; Gao, F. Simultaneous Determination of Dopamine, Serotonin and Ascorbic Acid at a Glassy Carbon Electrode Modified with Carbon-Spheres. Sensors 2013, 13, 14029-14040.

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