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Simultaneous Determination of Dopamine, Serotonin and Ascorbic Acid at a Glassy Carbon Electrode Modified with Carbon-Spheres
Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB), Key Laboratory of Chemo/Biosensing, Anhui Province, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China,
Department of Pharmacy, Anhui Medical College, Hefei 230601, China
College of Chemistry and Chemical Engineering, Fuyang Teachers College, Fuyang 236041, China
Department of Chemistry and Food Science, Chizhou College, Chizhou 247000, China
* Author to whom correspondence should be addressed.
Received: 7 September 2013; in revised form: 6 October 2013 / Accepted: 12 October 2013 / Published: 16 October 2013
Abstract: A novel glassy carbon electrode (GCE) modiﬁed with carbon-spheres has been fabricated through a simple casting procedure. The modified GCE displays high selectivity and excellent electrochemical catalytic activities towards dopamine (DA), serotonin (5-HT), and ascorbic acid (AA). In the co-existence system, the peak separations between AA and DA, DA and 5-HT, and AA and 5-HT are large up to 230, 180, and 410 mV, respectively. Differential pulse voltammetry (DPV) has been employed to simultaneously detect DA, 5-HT, and AA, and the linear calibration curves for DA, 5-HT, and AA are obtained in the range of 20.0–150.0 μM, 40.0–750.0 μM and 300.0–2,000.0 μM with detection limits (S/N = 3) of 2.0 μM, 0.7 μM and 0.6 μM, respectively. The proposed electrode has been applied to detect DA, 5-HT, and AA in real samples using standard addition method with satisfactory results.
Keywords: carbon-spheres; simultaneous determination; dopamine; ascorbic acid; serotonin
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Cite This Article
MDPI and ACS Style
Zhou, J.; Sheng, M.; Jiang, X.; Wu, G.; Gao, F. Simultaneous Determination of Dopamine, Serotonin and Ascorbic Acid at a Glassy Carbon Electrode Modified with Carbon-Spheres. Sensors 2013, 13, 14029-14040.
Zhou J, Sheng M, Jiang X, Wu G, Gao F. Simultaneous Determination of Dopamine, Serotonin and Ascorbic Acid at a Glassy Carbon Electrode Modified with Carbon-Spheres. Sensors. 2013; 13(10):14029-14040.
Zhou, Jianqing; Sheng, Meili; Jiang, Xueyue; Wu, Guozhi; Gao, Feng. 2013. "Simultaneous Determination of Dopamine, Serotonin and Ascorbic Acid at a Glassy Carbon Electrode Modified with Carbon-Spheres." Sensors 13, no. 10: 14029-14040.