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Sensors 2013, 13(10), 13960-13968; doi:10.3390/s131013960
Article

Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography

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Received: 16 September 2013; in revised form: 10 October 2013 / Accepted: 11 October 2013 / Published: 16 October 2013
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Spain 2013)
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Abstract: In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices.
Keywords: label-free; biosensor; surface plasmon resonance; nanohole array; nanoimprint lithography label-free; biosensor; surface plasmon resonance; nanohole array; nanoimprint lithography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Martinez-Perdiguero, J.; Retolaza, A.; Otaduy, D.; Juarros, A.; Merino, S. Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography. Sensors 2013, 13, 13960-13968.

AMA Style

Martinez-Perdiguero J, Retolaza A, Otaduy D, Juarros A, Merino S. Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography. Sensors. 2013; 13(10):13960-13968.

Chicago/Turabian Style

Martinez-Perdiguero, Josu; Retolaza, Aritz; Otaduy, Deitze; Juarros, Aritz; Merino, Santos. 2013. "Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography." Sensors 13, no. 10: 13960-13968.


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