Sensors 2013, 13(10), 13960-13968; doi:10.3390/s131013960
Article

Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography

1 CIC microGUNE, Arrasate-Mondragón 20500, Spain 2 Micro and Nanofabrication Unit, IK4-Tekniker, Eibar 20600, Spain
* Author to whom correspondence should be addressed.
Received: 16 September 2013; in revised form: 10 October 2013 / Accepted: 11 October 2013 / Published: 16 October 2013
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Spain 2013)
PDF Full-text Download PDF Full-Text [486 KB, uploaded 16 October 2013 12:14 CEST]
Abstract: In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices.
Keywords: label-free; biosensor; surface plasmon resonance; nanohole array; nanoimprint lithography

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Martinez-Perdiguero, J.; Retolaza, A.; Otaduy, D.; Juarros, A.; Merino, S. Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography. Sensors 2013, 13, 13960-13968.

AMA Style

Martinez-Perdiguero J, Retolaza A, Otaduy D, Juarros A, Merino S. Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography. Sensors. 2013; 13(10):13960-13968.

Chicago/Turabian Style

Martinez-Perdiguero, Josu; Retolaza, Aritz; Otaduy, Deitze; Juarros, Aritz; Merino, Santos. 2013. "Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography." Sensors 13, no. 10: 13960-13968.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert