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Sensors 2013, 13(10), 13960-13968; doi:10.3390/s131013960
Article

Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography

1,* , 1,2
,
1,2
,
1,2
 and
1,2
1 CIC microGUNE, Arrasate-Mondragón 20500, Spain 2 Micro and Nanofabrication Unit, IK4-Tekniker, Eibar 20600, Spain
* Author to whom correspondence should be addressed.
Received: 16 September 2013 / Revised: 10 October 2013 / Accepted: 11 October 2013 / Published: 16 October 2013
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Spain 2013)
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Abstract

In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices.
Keywords: label-free; biosensor; surface plasmon resonance; nanohole array; nanoimprint lithography label-free; biosensor; surface plasmon resonance; nanohole array; nanoimprint lithography
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Martinez-Perdiguero, J.; Retolaza, A.; Otaduy, D.; Juarros, A.; Merino, S. Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography. Sensors 2013, 13, 13960-13968.

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