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Sensors 2013, 13(10), 12794-12803; doi:10.3390/s131012794
Article

A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin

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Received: 18 July 2013 / Revised: 12 September 2013 / Accepted: 17 September 2013 / Published: 25 September 2013
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Abstract

In this study a novel sensitive nanogold particle sensor enhancement based on mixed self-assembled monolayers was explored and used to construct a Surface Plasmon Resonance (SPR) immunosensor to detect Ischemia Modified Albumin (IMA). Compared with a direct binding SPR assay at a limit of detection (LOD) of 100 ng/L, gold nanoparticles (AuNPs) of 10 nm dramatically improved the LOD of IMA to 10 ng/L. Meanwhile, no interfering substance that may lead to false positive results was identified. These results suggested that the SPR biosensor presented superior properties, and provided a simple label-free strategy to increase assay sensitivity for further acute coronary syndrome (ACS) diagnosis.
Keywords: ischemia modified albumin; surface plasmon resonance immunosensor; gold nanoparticles; signal enhancement ischemia modified albumin; surface plasmon resonance immunosensor; gold nanoparticles; signal enhancement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, G.; Li, X.; Yang, M.; Chen, M.-M.; Chen, L.-C.; Xiong, X.-L. A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin. Sensors 2013, 13, 12794-12803.

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