Sensors 2013, 13(10), 12794-12803; doi:10.3390/s131012794
Article

A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin

1email, 2email, 1email, 1email, 1,* email and 1,* email
Received: 18 July 2013; in revised form: 12 September 2013 / Accepted: 17 September 2013 / Published: 25 September 2013
View Full-Text   |   Download PDF [649 KB, uploaded 21 June 2014]
Abstract: In this study a novel sensitive nanogold particle sensor enhancement based on mixed self-assembled monolayers was explored and used to construct a Surface Plasmon Resonance (SPR) immunosensor to detect Ischemia Modified Albumin (IMA). Compared with a direct binding SPR assay at a limit of detection (LOD) of 100 ng/L, gold nanoparticles (AuNPs) of 10 nm dramatically improved the LOD of IMA to 10 ng/L. Meanwhile, no interfering substance that may lead to false positive results was identified. These results suggested that the SPR biosensor presented superior properties, and provided a simple label-free strategy to increase assay sensitivity for further acute coronary syndrome (ACS) diagnosis.
Keywords: ischemia modified albumin; surface plasmon resonance immunosensor; gold nanoparticles; signal enhancement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Li, G.; Li, X.; Yang, M.; Chen, M.-M.; Chen, L.-C.; Xiong, X.-L. A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin. Sensors 2013, 13, 12794-12803.

AMA Style

Li G, Li X, Yang M, Chen M-M, Chen L-C, Xiong X-L. A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin. Sensors. 2013; 13(10):12794-12803.

Chicago/Turabian Style

Li, Guang; Li, Xian; Yang, Meng; Chen, Meng-Meng; Chen, Long-Cong; Xiong, Xing-Liang. 2013. "A Gold Nanoparticles Enhanced Surface Plasmon Resonance Immunosensor for Highly Sensitive Detection of Ischemia-Modified Albumin." Sensors 13, no. 10: 12794-12803.


Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert