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Sensors 2012, 12(8), 11238-11248; doi:10.3390/s120811238

Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor

1
Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-Gu, Daejeon 305-700, Korea
2
Chemistry Institute for Functional Materials, Department of Chemistry, Pusan National University, Busan 609-735, Korea
*
Author to whom correspondence should be addressed.
Received: 24 July 2012 / Revised: 8 August 2012 / Accepted: 9 August 2012 / Published: 13 August 2012
(This article belongs to the Section Biosensors)
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Abstract

This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA. View Full-Text
Keywords: biosensor; F8T2; organic semiconductor; fluorescence; OTFT; biotin; avidin biosensor; F8T2; organic semiconductor; fluorescence; OTFT; biotin; avidin
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kim, Z.-S.; Lim, S.C.; Kim, S.H.; Yang, Y.S.; Hwang, D.-H. Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor. Sensors 2012, 12, 11238-11248.

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