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Sensors 2012, 12(8), 11238-11248; doi:10.3390/s120811238
Article

Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor

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Received: 24 July 2012; in revised form: 8 August 2012 / Accepted: 9 August 2012 / Published: 13 August 2012
(This article belongs to the Section Biosensors)
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Abstract: This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.
Keywords: biosensor; F8T2; organic semiconductor; fluorescence; OTFT; biotin; avidin biosensor; F8T2; organic semiconductor; fluorescence; OTFT; biotin; avidin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, Z.-S.; Lim, S.C.; Kim, S.H.; Yang, Y.S.; Hwang, D.-H. Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor. Sensors 2012, 12, 11238-11248.

AMA Style

Kim Z-S, Lim SC, Kim SH, Yang YS, Hwang D-H. Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor. Sensors. 2012; 12(8):11238-11248.

Chicago/Turabian Style

Kim, Zin-Sig; Lim, Sang Chul; Kim, Seong Hyun; Yang, Yong Suk; Hwang, Do-Hoon. 2012. "Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor." Sensors 12, no. 8: 11238-11248.


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