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Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor
Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-Gu, Daejeon 305-700, Korea
Chemistry Institute for Functional Materials, Department of Chemistry, Pusan National University, Busan 609-735, Korea
* Author to whom correspondence should be addressed.
Received: 24 July 2012; in revised form: 8 August 2012 / Accepted: 9 August 2012 / Published: 13 August 2012
Abstract: This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.
Keywords: biosensor; F8T2; organic semiconductor; fluorescence; OTFT; biotin; avidin
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Kim, Z.-S.; Lim, S.C.; Kim, S.H.; Yang, Y.S.; Hwang, D.-H. Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor. Sensors 2012, 12, 11238-11248.
Kim Z-S, Lim SC, Kim SH, Yang YS, Hwang D-H. Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor. Sensors. 2012; 12(8):11238-11248.
Kim, Zin-Sig; Lim, Sang Chul; Kim, Seong Hyun; Yang, Yong Suk; Hwang, Do-Hoon. 2012. "Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor." Sensors 12, no. 8: 11238-11248.