Sensors 2012, 12(5), 5986-5995; doi:10.3390/s120505986
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Eag1 Channels as Potential Cancer Biomarkers

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Received: 8 March 2012; in revised form: 27 March 2012 / Accepted: 5 April 2012 / Published: 10 May 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cancer is a leading cause of death worldwide. New early tumor markers are needed to treat the disease at curable stages. In addition, new therapeutic targets are required to treat patients not responding to available treatments. Ion channels play major roles in health and disease, including cancer. Actually, several ion channels have been suggested as potential tumor markers and therapeutic targets for different types of malignancies. One of most studied ion channels in cancer is the voltage-gated potassium channel Eag1 (ether à go-go 1), which has a high potential to be used as a cancer biomarker. Eag1 is expressed in most human tumors, in contrast to its restricted distribution in healthy tissues. Several findings suggest Eag1 as a potential early marker for cervical, colon, and breast cancer. In addition, because Eag1 amplification/expression is associated with poor survival in leukemia, colon and ovarian cancer patients, it has also been proposed as a prognosis marker. Moreover, inhibition of either expression or activity of Eag1 leads to reduced proliferation of cancer cells, making Eag1 a potential anticancer target. Using Eag1 in cancer detection programs could help to reduce mortality from this disease.
Keywords: ether à-go-go; tumor markers; prognostic markers; cervical cancer; human papilloma virus; estrogens; leukemia; colon cancer; potassium channels
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MDPI and ACS Style

Rodríguez-Rasgado, J.A.; Acuña-Macías, I.; Camacho, J. Eag1 Channels as Potential Cancer Biomarkers. Sensors 2012, 12, 5986-5995.

AMA Style

Rodríguez-Rasgado JA, Acuña-Macías I, Camacho J. Eag1 Channels as Potential Cancer Biomarkers. Sensors. 2012; 12(5):5986-5995.

Chicago/Turabian Style

Rodríguez-Rasgado, Jesús Adrián; Acuña-Macías, Isabel; Camacho, Javier. 2012. "Eag1 Channels as Potential Cancer Biomarkers." Sensors 12, no. 5: 5986-5995.

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