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Sensors 2012, 12(2), 2284-2308; doi:10.3390/s120202284

Biomarker Discovery by Novel Sensors Based on Nanoproteomics Approaches

1
Centro de Investigación del Cáncer/IBMCC (USAL/CSIC), Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca 37007, Spain
2
Departamento de Química Analítica, Facultad de Ciencias Químicas, University of Salamanca, Salamanca 37008, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 1 December 2011 / Revised: 20 January 2012 / Accepted: 14 February 2012 / Published: 16 February 2012
(This article belongs to the Special Issue Biomarkers and Nanosensors: New Approaches for Biology and Medicine)
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Abstract

During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and applications in biomarker discovery. In addition, several disease biomarkers are shown in order to display the clinical importance of the improvement of sensitivity and selectivity by using nanoproteomics approaches as novel sensors. View Full-Text
Keywords: biomarker; cancer; nanosensor; high-throughput techniques; microarray; proteomics biomarker; cancer; nanosensor; high-throughput techniques; microarray; proteomics
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dasilva, N.; Díez, P.; Matarraz, S.; González-González, M.; Paradinas, S.; Orfao, A.; Fuentes, M. Biomarker Discovery by Novel Sensors Based on Nanoproteomics Approaches. Sensors 2012, 12, 2284-2308.

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