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Sensors 2012, 12(12), 16867-16878; doi:10.3390/s121216867

Investigation into the Effect of Varied Functional Biointerfaces on Silicon Nanowire MOSFETs

1
Graduate Institute of Biomedical Engineering, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan
2
National Nano Device Laboratories, 26 Prosperity Road 1, Hsinchu Science Park, Hsinchu 30078, Taiwan
*
Author to whom correspondence should be addressed.
Received: 8 October 2012 / Revised: 29 November 2012 / Accepted: 3 December 2012 / Published: 6 December 2012
(This article belongs to the Section Biosensors)
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Abstract

A biocompatible and functional interface can improve the sensitivity of bioelectronics. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor field effect transistors (NW-MOSFETs). Those SAMs-modified silicon NW-MOSFETs were used to discriminate various pH solutions and further verify which modified regime was capable of providing better electrical signals. The APTMS-SAM modified NW-MOSFETs showed better electrical responses in pH sensing. Biomolecules on APTMS-SAM modified NW-MOSFETs also gave better signals for the corresponding proteind in physiological buffer solutions. Atomic force microscopy (AFM) clarified those electrical phenomena and found biomolecules on APTMS-SAM were relatively uniformly modified on NW-MOSFETs. Our results showed that more uniform modification contributed to better signal response to protein interactions in physiological buffer solutions. It suggests that suitable surface modifications could profoundly affect the sensing response and sensitivity.
Keywords: functional biointerface; surface modification; electrical measurement; pH sensing; protein interaction functional biointerface; surface modification; electrical measurement; pH sensing; protein interaction
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MDPI and ACS Style

Lin, S.-P.; Chi, T.-Y.; Lai, T.-Y.; Liu, M.-C. Investigation into the Effect of Varied Functional Biointerfaces on Silicon Nanowire MOSFETs. Sensors 2012, 12, 16867-16878.

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