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Overview of Micro- and Nano-Technology Tools for Stem Cell Applications: Micropatterned and Microelectronic Devices
Department of Biology and CRIBI Biotechnology Centre, University of Padova, via U. Bassi 58/B, 35121 Padova, Italy
Department of Biomedical Engineering, Columbia University, Vanderbilt Clinic Room 12-234, 630 West 168th Street, New York, NY 10032, USA
CLSE IBI-EPFL, Swiss Up Chair on Engineering, Laboratory of Life Sciences Electronics, Institute of Bioengineering, Ecole polytechnique Fédérale de Lausanne BM 2106, Station 17, CH-1015 Lausanne, Switzerland
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 September 2012; in revised form: 10 November 2012 / Accepted: 15 November 2012 / Published: 19 November 2012
Abstract: In the past few decades the scientific community has been recognizing the paramount role of the cell microenvironment in determining cell behavior. In parallel, the study of human stem cells for their potential therapeutic applications has been progressing constantly. The use of advanced technologies, enabling one to mimic the in vivo stem cell microenviroment and to study stem cell physiology and physio-pathology, in settings that better predict human cell biology, is becoming the object of much research effort. In this review we will detail the most relevant and recent advances in the field of biosensors and micro- and nano-technologies in general, highlighting advantages and disadvantages. Particular attention will be devoted to those applications employing stem cells as a sensing element.
Keywords: cell biosensor; micropattern; stem cell; cell microelectronic chip; cell microarray; microbioreactor
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Cagnin, S.; Cimetta, E.; Guiducci, C.; Martini, P.; Lanfranchi, G. Overview of Micro- and Nano-Technology Tools for Stem Cell Applications: Micropatterned and Microelectronic Devices. Sensors 2012, 12, 15947-15982.
Cagnin S, Cimetta E, Guiducci C, Martini P, Lanfranchi G. Overview of Micro- and Nano-Technology Tools for Stem Cell Applications: Micropatterned and Microelectronic Devices. Sensors. 2012; 12(11):15947-15982.
Cagnin, Stefano; Cimetta, Elisa; Guiducci, Carlotta; Martini, Paolo; Lanfranchi, Gerolamo. 2012. "Overview of Micro- and Nano-Technology Tools for Stem Cell Applications: Micropatterned and Microelectronic Devices." Sensors 12, no. 11: 15947-15982.