Sensors 2012, 12(11), 15907-15946; doi:10.3390/s121115907
Review

Thiol Reactive Probes and Chemosensors

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Received: 24 September 2012; in revised form: 12 November 2012 / Accepted: 13 November 2012 / Published: 19 November 2012
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Abstract: Thiols are important molecules in the environment and in biological processes. Cysteine (Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) play critical roles in a variety of physiological and pathological processes. The selective detection of thiols using reaction-based probes and sensors is very important in basic research and in disease diagnosis. This review focuses on the design of fluorescent and colorimetric probes and sensors for thiol detection. Thiol detection methods include probes and labeling agents based on nucleophilic addition and substitution, Michael addition, disulfide bond or Se-N bond cleavage, metal-sulfur interactions and more. Probes for H2S are based on nucleophilic cyclization, reduction and metal sulfide formation. Thiol probe and chemosensor design strategies and mechanism of action are discussed in this review.
Keywords: thiols; cysteine; homocysteine; glutathione; hydrogen sulfide; sensors; probes; detection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Peng, H.; Chen, W.; Cheng, Y.; Hakuna, L.; Strongin, R.; Wang, B. Thiol Reactive Probes and Chemosensors. Sensors 2012, 12, 15907-15946.

AMA Style

Peng H, Chen W, Cheng Y, Hakuna L, Strongin R, Wang B. Thiol Reactive Probes and Chemosensors. Sensors. 2012; 12(11):15907-15946.

Chicago/Turabian Style

Peng, Hanjing; Chen, Weixuan; Cheng, Yunfeng; Hakuna, Lovemore; Strongin, Robert; Wang, Binghe. 2012. "Thiol Reactive Probes and Chemosensors." Sensors 12, no. 11: 15907-15946.


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