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Sensors 2012, 12(10), 13753-13780; doi:10.3390/s121013753
Review

Italian Contributions to the Development of Continuous Glucose Monitoring Sensors for Diabetes Management

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Received: 12 September 2012; in revised form: 8 October 2012 / Accepted: 10 October 2012 / Published: 12 October 2012
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Italy 2012)
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Abstract: Monitoring glucose concentration in the blood is essential in the therapy of diabetes, a pathology which affects about 350 million people around the World (three million in Italy), causes more than four million deaths per year and consumes a significant portion of the budget of national health systems (10% in Italy). In the last 15 years, several sensors with different degree of invasiveness have been proposed to monitor glycemia in a quasi-continuous way (up to 1 sample/min rate) for relatively long intervals (up to 7 consecutive days). These continuous glucose monitoring (CGM) sensors have opened new scenarios to assess, off-line, the effectiveness of individual patient therapeutic plans from the retrospective analysis of glucose time-series, but have also stimulated the development of innovative on-line applications, such as hypo/hyper-glycemia alert systems and artificial pancreas closed-loop control algorithms. In this review, we illustrate some significant Italian contributions, both from industry and academia, to the growth of the CGM sensors research area. In particular, technological, algorithmic and clinical developments performed in Italy will be discussed and put in relation with the advances obtained in the field in the wider international research community.
Keywords: diabetes; biosensors; non-invasive sensors; glucose-oxidase; signal processing; sensor calibration; model; time-series diabetes; biosensors; non-invasive sensors; glucose-oxidase; signal processing; sensor calibration; model; time-series
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sparacino, G.; Zanon, M.; Facchinetti, A.; Zecchin, C.; Maran, A.; Cobelli, C. Italian Contributions to the Development of Continuous Glucose Monitoring Sensors for Diabetes Management. Sensors 2012, 12, 13753-13780.

AMA Style

Sparacino G, Zanon M, Facchinetti A, Zecchin C, Maran A, Cobelli C. Italian Contributions to the Development of Continuous Glucose Monitoring Sensors for Diabetes Management. Sensors. 2012; 12(10):13753-13780.

Chicago/Turabian Style

Sparacino, Giovanni; Zanon, Mattia; Facchinetti, Andrea; Zecchin, Chiara; Maran, Alberto; Cobelli, Claudio. 2012. "Italian Contributions to the Development of Continuous Glucose Monitoring Sensors for Diabetes Management." Sensors 12, no. 10: 13753-13780.


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