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Sensors 2011, 11(9), 8813-8825; doi:10.3390/s110908813
Article

Use of a New Ziprasidone-Selective Electrode in Mixed Solvents and Its Application in the Analysis of Pharmaceuticals and Biological Fluids

* ,
,
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Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E-30100 Murcia, Spain
* Author to whom correspondence should be addressed.
Received: 4 August 2011 / Revised: 7 September 2011 / Accepted: 8 September 2011 / Published: 13 September 2011
(This article belongs to the Section Physical Sensors)
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Abstract

The construction and characterization of a new ion-selective electrode for the determination of the antipsychotic ziprasidone in mixed solvents is presented. The electrode contains a plasticized polymeric membrane based on a ziprasidone-tetraphenylborate ion-exchanger. The influence of membrane composition on the electrode response towards ziprasidone in hydroalcoholic solutions was studied. The electrode displayed a stable response in a 2:3 (v/v) methanol/water medium from a ziprasidone concentration of 3 × 10−6 M with a fast response time of less than 20 s. The electrode also showed good selectivity towards ziprasidone over common inorganic and organic compounds and several species with pharmacological activity. The electrode was successfully applied to the determination of ziprasidone in pharmaceuticals and human urine and serum.
Keywords: ion-selective electrode; ziprasidone; mixed solvents; pharmaceuticals; urine; serum ion-selective electrode; ziprasidone; mixed solvents; pharmaceuticals; urine; serum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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García, M.S.; Ortuño, J.A.; Cuartero, M.; Abuherba, M.S. Use of a New Ziprasidone-Selective Electrode in Mixed Solvents and Its Application in the Analysis of Pharmaceuticals and Biological Fluids. Sensors 2011, 11, 8813-8825.

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