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Sensors 2011, 11(8), 7851-7864; doi:10.3390/s110807851

Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies

1
Department of Optics and Photonics, National Central University, 300 Chung-Da Rd., Chung-Li 32001, Taiwan
2
Department of Electrical Engineering, National Central University, 300 Chung-Da Rd., Chung-Li 32001, Taiwan
*
Author to whom correspondence should be addressed.
Received: 17 June 2011 / Revised: 23 July 2011 / Accepted: 8 August 2011 / Published: 11 August 2011
(This article belongs to the Section Biosensors)
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Abstract

This paper describes a method for producing a novel type of ferromagnetic coded micro-carrier. The ferromagnetic coded micro-carriers are about 200 μm in length, 200 μm in width and 50 μm in thickness, and contain eight code elements with two distinguishable codes (hollow and solid), allowing for 28 unique codes. The code shapes include rectangle, circle, etc. Differently shaped coded micro-carriers could carry different antigens for detection of its complementary antibody. These many shapes of coded micro-carriers would be used simultaneously allowing us to make multiple detections for different antibodies at the same time. A molding process is applied for fabrication of the ferromagnetically coded micro-carriers where Fe material (Fe powder mixed with binder) is shaped in many tiny molds to produce the coded shapes used for identification of the bio-molecules. Magnetic force is used to control the movement and location of the ferromagnetic coded micro-carriers to prevent the loss during the hybridization process. The results of image process and analysis system testing are satisfactory. The results of our micro-carrier detection system for two sets of R and B color analysis are proportional to those obtained from ELISA antibody detection. View Full-Text
Keywords: ferromagnetic coded micro-carrier; magnetic force; hybridization ferromagnetic coded micro-carrier; magnetic force; hybridization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chang, R.-S.; Tsai, J.-Z.; Li, T.-Y. Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies. Sensors 2011, 11, 7851-7864.

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