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Sensors 2011, 11(12), 11736-11751; doi:10.3390/s111211736
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Semiconductor Quantum Dots for Biomedicial Applications

,
 and *
Jiangsu Affiliated Cancer Hospital with Nanjing Medical University, Jiangsu Institute of Cancer Prevention and Cure, Nanjing 210009, China
* Author to whom correspondence should be addressed.
Received: 2 November 2011 / Revised: 6 December 2011 / Accepted: 13 December 2011 / Published: 16 December 2011
(This article belongs to the Special Issue Sensing with Quantum Dots)
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Abstract

Semiconductor quantum dots (QDs) are nanometre-scale crystals, which have unique photophysical properties, such as size-dependent optical properties, high fluorescence quantum yields, and excellent stability against photobleaching. These properties enable QDs as the promising optical labels for the biological applications, such as multiplexed analysis of immunocomplexes or DNA hybridization processes, cell sorting and tracing, in vivo imaging and diagnostics in biomedicine. Meanwhile, QDs can be used as labels for the electrochemical detection of DNA or proteins. This article reviews the synthesis and toxicity of QDs and their optical and electrochemical bioanalytical applications. Especially the application of QDs in biomedicine such as delivering, cell targeting and imaging for cancer research, and in vivo photodynamic therapy (PDT) of cancer are briefly discussed.
Keywords: quantum dots; bioanalysis; toxicology delivery; photodynamic therapy; cell imaging quantum dots; bioanalysis; toxicology delivery; photodynamic therapy; cell imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shao, L.; Gao, Y.; Yan, F. Semiconductor Quantum Dots for Biomedicial Applications. Sensors 2011, 11, 11736-11751.

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