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Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions
Institute for Microelectronics and Microsystems, Naples Unit, National Research Council, Via P. Castellino 111, 80131 Napoli, Italy
Department of Physics, University of Naples “Federico II”, Via Cinthia, 80128 Napoli, Italy
* Author to whom correspondence should be addressed.
Received: 16 September 2011; in revised form: 7 October 2011 / Accepted: 9 October 2011 / Published: 12 October 2011
Abstract: Finite element method analysis was applied to the characterization of the biomolecular interactions taking place in a microfluidic assisted microarray. Numerical simulations have been used for the optimization of geometrical and physical parameters of the sensing device. Different configurations have been analyzed and general considerations have been derived. We have shown that a parallel disposition of the sensing area allows the homogeneous formation of the target molecular complex in all the active zones of the microarray. Stationary and time dependent results have also been obtained.
Keywords: microfluidics; biosensing; reaction kinetics
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MDPI and ACS Style
Orabona, E.; Rea, I.; Rendina, I.; Stefano, L.D. Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions. Sensors 2011, 11, 9658-9666.
Orabona E, Rea I, Rendina I, Stefano LD. Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions. Sensors. 2011; 11(10):9658-9666.
Orabona, Emanuele; Rea, Ilaria; Rendina, Ivo; Stefano, Luca De. 2011. "Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions." Sensors 11, no. 10: 9658-9666.