Sensors 2010, 10(8), 7789-7802; doi:10.3390/s100807789
Article

Acute Response in vivo of a Fiber-Optic Sensor for Continuous Glucose Monitoring from Canine Studies on Point Accuracy

1 Graduate Institute of Biomedical Engineering, National Chung-Hsing University, 250 Kuo-Kuang Rd., Taichung City, 40227, Taiwan 2 Department of Veterinary Medicine / Veterinary Medical Teaching Hospital, National Chung-Hsing University, 250 Kuo-Kuang Rd., Taichung City, 40227, Taiwan
* Author to whom correspondence should be addressed.
Received: 22 June 2010; in revised form: 26 July 2010 / Accepted: 5 August 2010 / Published: 20 August 2010
(This article belongs to the Special Issue Glucose Sensors)
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Abstract: The objective of this study was to evaluate the acute response of SencilTM, a fiber-optic sensor, in point accuracy for glucose monitoring in vivo on healthy dogs under anesthesia.  A total of four dogs with clinically normal glycemia were implanted with one sensor each in the chest region to measure the interstitial glucose concentration during the ovariohysterectomy procedure. The data was acquired every 10 seconds after initiation, and was compared to the concentration of venous plasma glucose sampled during the surgery procedures for accuracy of agreement analysis. In the four trials with a range of 71–297 mg/dL plasma glucose, the collected 21 pairs of ISF readings from the SencilTM and the plasma reference showed superior dispersion of residue values than the conventional system, and a linear correlation (the Pearson correlation coefficient is 0.9288 and the y-intercept is 14.22 mg/dL). The MAD (17.6 mg/dL) and RMAD (16.16%) of SencilTM measurements were in the comparable range of the conventional system. The Clarke error grid analysis indicated that 100% of the paired points were in the clinically acceptable zone A (61.9%) and B (38.1%).
Keywords: in vivo glucose monitoring; fiber-optic sensor; point accuracy; Clarke error grid analysis; calibration

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MDPI and ACS Style

Liao, K.-C.; Chang, S.-C.; Chiu, C.-Y.; Chou, Y.-H. Acute Response in vivo of a Fiber-Optic Sensor for Continuous Glucose Monitoring from Canine Studies on Point Accuracy. Sensors 2010, 10, 7789-7802.

AMA Style

Liao K-C, Chang S-C, Chiu C-Y, Chou Y-H. Acute Response in vivo of a Fiber-Optic Sensor for Continuous Glucose Monitoring from Canine Studies on Point Accuracy. Sensors. 2010; 10(8):7789-7802.

Chicago/Turabian Style

Liao, Kuo-Chih; Chang, Shih-Chieh; Chiu, Cheng-Yang; Chou, Yu-Hsiang. 2010. "Acute Response in vivo of a Fiber-Optic Sensor for Continuous Glucose Monitoring from Canine Studies on Point Accuracy." Sensors 10, no. 8: 7789-7802.

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