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Sensors 2010, 10(7), 6535-6581; doi:10.3390/s100706535

Prospects of Nanotechnology in Clinical Immunodiagnostics

1
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia
2
Department of Chemical Engineering, College of Engineering, King Saud University, Riyadh-11451, P.O. Box-2454, Saudi Arabia
3
Department of Physics and Astronomy, College of Science, King Saud University, Riyadh-11451, P.O. Box-2455, Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 30 May 2010 / Revised: 12 June 2010 / Published: 7 July 2010
(This article belongs to the Special Issue Immunosensors)
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Abstract

Nanostructured materials are promising compounds that offer new opportunities as sensing platforms for the detection of biomolecules. Having micrometer-scale length and nanometer-scale diameters, nanomaterials can be manipulated with current nanofabrication methods, as well as self-assembly techniques, to fabricate nanoscale bio-sensing devices. Nanostructured materials possess extraordinary physical, mechanical, electrical, thermal and multifunctional properties. Such unique properties advocate their use as biomimetic membranes to immobilize and modify biomolecules on the surface of nanoparticles. Alignment, uniform dispersion, selective growth and diameter control are general parameters which play critical roles in the successful integration of nanostructures for the fabrication of bioelectronic sensing devices. In this review, we focus on different types and aspects of nanomaterials, including their synthesis, properties, conjugation with biomolecules and their application in the construction of immunosensing devices. Some key results from each cited article are summarized by relating the concept and mechanism behind each sensor, experimental conditions and the behavior of the sensor under different conditions, etc. The variety of nanomaterial-based bioelectronic devices exhibiting novel functions proves the unique properties of nanomaterials in such sensing devices, which will surely continue to expand in the future. Such nanomaterial based devices are expected to have a major impact in clinical immunodiagnostics, environmental monitoring, security surveillance and for ensuring food safety.
Keywords: nanotechnology; antibody; antigen; nanomaterials; immune-biosensors nanotechnology; antibody; antigen; nanomaterials; immune-biosensors
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ansari, A.A.; Alhoshan, M.; Alsalhi, M.S.; Aldwayyan, A.S. Prospects of Nanotechnology in Clinical Immunodiagnostics. Sensors 2010, 10, 6535-6581.

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