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Sonochemically Fabricated Microelectrode Arrays for Use as Sensing Platforms
Microarray Ltd, PO BOX 88, Manchester, M60 1QD, UK
Cranfield Health, Cranfield University, Cranfield, Bedfordshire, MK43 0AL, UK
* Author to whom correspondence should be addressed.
Received: 26 January 2010; in revised form: 15 April 2010 / Accepted: 27 April 2010 / Published: 25 May 2010
Abstract: The development, manufacture, modification and subsequent utilisation of sonochemically-formed microelectrode arrays is described for a range of applications. Initial fabrication of the sensing platform utilises ultrasonic ablation of electrochemically insulating polymers deposited upon conductive carbon substrates, forming an array of up to 70,000 microelectrode pores cm–2. Electrochemical and optical analyses using these arrays, their enhanced signal response and stir-independence area are all discussed. The growth of conducting polymeric “mushroom” protrusion arrays with entrapped biological entities, thereby forming biosensors is detailed. The simplicity and inexpensiveness of this approach, lending itself ideally to mass fabrication coupled with unrivalled sensitivity and stir independence makes commercial viability of this process a reality. Application of microelectrode arrays as functional components within sensors include devices for detection of chlorine, glucose, ethanol and pesticides. Immunosensors based on microelectrode arrays are described within this monograph for antigens associated with prostate cancer and transient ischemic attacks (strokes).
Keywords: microelectrodes; arrays; fabrication; surface modification; enzymes
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MDPI and ACS Style
Collyer, S.D.; Davis, F.; Higson, S.P. Sonochemically Fabricated Microelectrode Arrays for Use as Sensing Platforms. Sensors 2010, 10, 5090-5132.
Collyer SD, Davis F, Higson SP. Sonochemically Fabricated Microelectrode Arrays for Use as Sensing Platforms. Sensors. 2010; 10(5):5090-5132.
Collyer, Stuart D.; Davis, Frank; Higson, Séamus P.J. 2010. "Sonochemically Fabricated Microelectrode Arrays for Use as Sensing Platforms." Sensors 10, no. 5: 5090-5132.