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Sensors 2010, 10(1), 97-111; doi:10.3390/s100100097

The Inflammasome in Host Defense

Center for Disease Vector Research and Department of Entomology, University of California-Riverside, Riverside, 92521, CA, USA
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Author to whom correspondence should be addressed.
Received: 2 December 2009 / Revised: 17 December 2009 / Accepted: 18 December 2009 / Published: 28 December 2009
(This article belongs to the Special Issue Dendritic Sensors: From Dendrimer Molecules to Dendritic Cells)
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Abstract

Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes.
Keywords: inflammasome; nod-like receptors; innate immunity inflammasome; nod-like receptors; innate immunity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, G.; Pedra, J.H. The Inflammasome in Host Defense. Sensors 2010, 10, 97-111.

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