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The Inflammasome in Host Defense
Center for Disease Vector Research and Department of Entomology, University of California-Riverside, Riverside, 92521, CA, USA
* Author to whom correspondence should be addressed.
Received: 2 December 2009; in revised form: 17 December 2009 / Accepted: 18 December 2009 / Published: 28 December 2009
Abstract: Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes.
Keywords: inflammasome; nod-like receptors; innate immunity
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Cite This Article
MDPI and ACS Style
Chen, G.; Pedra, J.H. The Inflammasome in Host Defense. Sensors 2010, 10, 97-111.
Chen G, Pedra JH. The Inflammasome in Host Defense. Sensors. 2010; 10(1):97-111.
Chen, Gang; Pedra, Joao H. 2010. "The Inflammasome in Host Defense." Sensors 10, no. 1: 97-111.