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Sensors 2009, 9(9), 6730-6751; doi:10.3390/s90906730
Review

Dendritic Cells as Danger-Recognizing Biosensors

,
 and
*
Department of Bioscience and Biotechnology, College of Life Science, Sejong University, Seoul, 143-747, Korea
* Author to whom correspondence should be addressed.
Received: 2 July 2009 / Revised: 19 August 2009 / Accepted: 24 August 2009 / Published: 27 August 2009
(This article belongs to the Special Issue Dendritic Sensors: From Dendrimer Molecules to Dendritic Cells)
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Abstract

Dendritic cells (DCs) are antigen presenting cells that are characterized by a potent capacity to initiate immune responses. DCs comprise several subsets with distinct phenotypes. After sensing any danger(s) to the host via their innate immune receptors such as Toll-like receptors, DCs become mature and subsequently present antigens to CD4+ T cells. Since DCs possess the intrinsic capacity to polarize CD4+ helper cells, it is critical to understand the immunological roles of DCs for clinical applications. Here, we review the different DC subsets, their danger-sensing receptors and immunological functions. Furthermore, the cytokine reporter mouse model for studying DC activation is introduced.
Keywords: dendritic cells; toll-like receptors; pathogen-associated molecular patterns; Interleukin 12; cytokine reporter mouse model dendritic cells; toll-like receptors; pathogen-associated molecular patterns; Interleukin 12; cytokine reporter mouse model
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Gi, M.; Im, W.; Hong, S. Dendritic Cells as Danger-Recognizing Biosensors. Sensors 2009, 9, 6730-6751.

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