Sensors 2009, 9(9), 6730-6751; doi:10.3390/s90906730

Dendritic Cells as Danger-Recognizing Biosensors

email, email and * email
Received: 2 July 2009; in revised form: 19 August 2009 / Accepted: 24 August 2009 / Published: 27 August 2009
(This article belongs to the Special Issue Dendritic Sensors: From Dendrimer Molecules to Dendritic Cells)
View Full-Text   |   Download PDF [1622 KB, uploaded 21 June 2014]
Abstract: Dendritic cells (DCs) are antigen presenting cells that are characterized by a potent capacity to initiate immune responses. DCs comprise several subsets with distinct phenotypes. After sensing any danger(s) to the host via their innate immune receptors such as Toll-like receptors, DCs become mature and subsequently present antigens to CD4+ T cells. Since DCs possess the intrinsic capacity to polarize CD4+ helper cells, it is critical to understand the immunological roles of DCs for clinical applications. Here, we review the different DC subsets, their danger-sensing receptors and immunological functions. Furthermore, the cytokine reporter mouse model for studying DC activation is introduced.
Keywords: dendritic cells; toll-like receptors; pathogen-associated molecular patterns; Interleukin 12; cytokine reporter mouse model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Gi, M.; Im, W.; Hong, S. Dendritic Cells as Danger-Recognizing Biosensors. Sensors 2009, 9, 6730-6751.

AMA Style

Gi M, Im W, Hong S. Dendritic Cells as Danger-Recognizing Biosensors. Sensors. 2009; 9(9):6730-6751.

Chicago/Turabian Style

Gi, Mia; Im, Wooseok; Hong, Seokmann. 2009. "Dendritic Cells as Danger-Recognizing Biosensors." Sensors 9, no. 9: 6730-6751.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert