Dendritic Cells as Danger-Recognizing Biosensors
AbstractDendritic cells (DCs) are antigen presenting cells that are characterized by a potent capacity to initiate immune responses. DCs comprise several subsets with distinct phenotypes. After sensing any danger(s) to the host via their innate immune receptors such as Toll-like receptors, DCs become mature and subsequently present antigens to CD4+ T cells. Since DCs possess the intrinsic capacity to polarize CD4+ helper cells, it is critical to understand the immunological roles of DCs for clinical applications. Here, we review the different DC subsets, their danger-sensing receptors and immunological functions. Furthermore, the cytokine reporter mouse model for studying DC activation is introduced.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Gi, M.; Im, W.; Hong, S. Dendritic Cells as Danger-Recognizing Biosensors. Sensors 2009, 9, 6730-6751.
Gi M, Im W, Hong S. Dendritic Cells as Danger-Recognizing Biosensors. Sensors. 2009; 9(9):6730-6751.Chicago/Turabian Style
Gi, Mia; Im, Wooseok; Hong, Seokmann. 2009. "Dendritic Cells as Danger-Recognizing Biosensors." Sensors 9, no. 9: 6730-6751.