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MicroRNA: an Emerging Therapeutic Target and Intervention Tool
Department of Pathology and Laboratory Medicine, University of British Columbia, The Heart and Lung Institute, St. Paul’s Hospital, Vancouver, Canada
* Author to whom correspondence should be addressed.
Received: 7 April 2008; in revised form: 16 May 2008 / Accepted: 27 May 2008 / Published: 13 June 2008
Abstract: MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. To date, more than 600 human miRNAs have been experimentally identified, and estimated to regulate more than one third of cellular messenger RNAs. Accumulating evidence has linked the dysregulated expression patterns of miRNAs to a variety of diseases, such as cancer, neurodegenerative diseases, cardiovascular diseases and viral infections. MiRNAs provide its particular layer of network for gene regulation, thus possessing the great potential both as a novel class of therapeutic targets and as a powerful intervention tool. In this regard, synthetic RNAs that contain the binding sites of miRNA have been shown to work as a “decoy” or “miRNA sponge” to inhibit the function of specific miRNAs. On the other hand, miRNA expression vectors have been used to restore or overexpress specific miRNAs to achieve a long-term effect. Further, double-stranded miRNA mimetics for transient replacement have been experimentally validated. Endogenous precursor miRNAs have also been used as scaffolds for the induction of RNA interference. This article reviews the recent progress on this emerging technology as a powerful tool for gene regulation studies and particularly as a rationale strategy for design of therapeutics.
Keywords: miRNA; siRNA; gene silencing; virus; RNAi; heart disease
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MDPI and ACS Style
Liu, Z.; Sall, A.; Yang, D. MicroRNA: an Emerging Therapeutic Target and Intervention Tool. Int. J. Mol. Sci. 2008, 9, 978-999.
Liu Z, Sall A, Yang D. MicroRNA: an Emerging Therapeutic Target and Intervention Tool. International Journal of Molecular Sciences. 2008; 9(6):978-999.
Liu, Zhen; Sall, Alhousseynou; Yang, Decheng. 2008. "MicroRNA: an Emerging Therapeutic Target and Intervention Tool." Int. J. Mol. Sci. 9, no. 6: 978-999.