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Int. J. Mol. Sci. 2008, 9(12), 2570-2584; doi:10.3390/ijms9122570

Zearalenone and Reproductive Function in Farm Animals

1,*  and 2
1 Institute of Sciences of Food Production (ISPA), National Research Council (CNR)/ Via G. Amendola 122/O, 70125 Bari, Italy 2 Department of Animal Production, University of Bari / Strada Provinciale Casamassima Km3, 70100 Valenzano, Italy
* Author to whom correspondence should be addressed.
Received: 3 November 2008 / Revised: 4 December 2008 / Accepted: 8 December 2008 / Published: 11 December 2008
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Farm animals are exposed to zearalenone through the feed because of the widespread occurrence of this mycotoxin in cereals and clinical reproductive disorders due to mycotoxin effects are often reported in farm animal species. This review describes the metabolism, the mechanistic aspects, the clinical reproductive symptoms and the in vitro effects on functional parameters of oocytes and sperm cells induced by zearalenone and its derivatives in farm animals. The studies on in vitro effects allow to understand the action mechanisms of mycotoxins and, sometime, to explain the in vivo symptoms. The impairment of semen quality and female reproductive function induced by zearalenone could be a factor responsible for the reproductive failure in farm animals.
Keywords: Zearalenone and its derivatives; farm animals; in vivo; in vitro Zearalenone and its derivatives; farm animals; in vivo; in vitro
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Minervini, F.; Dell’Aquila, M.E. Zearalenone and Reproductive Function in Farm Animals. Int. J. Mol. Sci. 2008, 9, 2570-2584.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert