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Zearalenone and Reproductive Function in Farm Animals
Institute of Sciences of Food Production (ISPA), National Research Council (CNR)/ Via G. Amendola 122/O, 70125 Bari, Italy
Department of Animal Production, University of Bari / Strada Provinciale Casamassima Km3, 70100 Valenzano, Italy
* Author to whom correspondence should be addressed.
Received: 3 November 2008; in revised form: 4 December 2008 / Accepted: 8 December 2008 / Published: 11 December 2008
Abstract: Farm animals are exposed to zearalenone through the feed because of the widespread occurrence of this mycotoxin in cereals and clinical reproductive disorders due to mycotoxin effects are often reported in farm animal species. This review describes the metabolism, the mechanistic aspects, the clinical reproductive symptoms and the in vitro effects on functional parameters of oocytes and sperm cells induced by zearalenone and its derivatives in farm animals. The studies on in vitro effects allow to understand the action mechanisms of mycotoxins and, sometime, to explain the in vivo symptoms. The impairment of semen quality and female reproductive function induced by zearalenone could be a factor responsible for the reproductive failure in farm animals.
Keywords: Zearalenone and its derivatives; farm animals; in vivo; in vitro
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Minervini, F.; Dell’Aquila, M.E. Zearalenone and Reproductive Function in Farm Animals. Int. J. Mol. Sci. 2008, 9, 2570-2584.
Minervini F, Dell’Aquila ME. Zearalenone and Reproductive Function in Farm Animals. International Journal of Molecular Sciences. 2008; 9(12):2570-2584.
Minervini, Fiorenza; Dell’Aquila, Maria Elena. 2008. "Zearalenone and Reproductive Function in Farm Animals." Int. J. Mol. Sci. 9, no. 12: 2570-2584.