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T-2 Toxin-induced Toxicity in Pregnant Mice and Rats
Nippon Institute for Biological Science, 9-2221-1, Shin-Machi, Ome, Tokyo 198-0024, Japan
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo, Tokyo 113-8657, Japan
Fukui Safety Research Laboratories, Ono Pharmaceutical Co., Ltd., 5-10 Yamagishi, Mikuni-Cho, Sakai-Shi, Fukui 913-0032, Japan
Daiichi Sankyo Inc., 399 Thornall Street, Edison, NJ 08837, USA
* Author to whom correspondence should be addressed.
Received: 17 October 2008; in revised form: 31 October 2008 / Accepted: 4 November 2008 / Published: 5 November 2008
Abstract: T-2 toxin is a cytotoxic secondary fungal metabolite that belongs to the trichothecene mycotoxin family. This mycotoxin is a well known inhibitor of protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the ribosomal 60s subunit, and it also inhibits the synthesis of DNA and RNA, probably secondary to the inhibition of protein synthesis. In addition, T-2 toxin is said to induce apoptosis in many types of cells bearing high proliferating activity. T-2 toxin readily passes the placenta and is distributed to embryo/fetal tissues, which include many component cells bearing high proliferating activity. This paper reviews the reported data related to T-2 toxin-induced maternal and fetal toxicities in pregnant mice and rats. The mechanisms of T-2 toxin-induced apoptosis in maternal and fetal tissues are also discussed in this paper.
Keywords: T-2 Toxin; maternal toxicity; fetal toxicity; apoptosis; mouse; rat
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Doi, K.; Ishigami, N.; Sehata, S. T-2 Toxin-induced Toxicity in Pregnant Mice and Rats. Int. J. Mol. Sci. 2008, 9, 2146-2158.
Doi K, Ishigami N, Sehata S. T-2 Toxin-induced Toxicity in Pregnant Mice and Rats. International Journal of Molecular Sciences. 2008; 9(11):2146-2158.
Doi, Kunio; Ishigami, Noriaki; Sehata, Shinya. 2008. "T-2 Toxin-induced Toxicity in Pregnant Mice and Rats." Int. J. Mol. Sci. 9, no. 11: 2146-2158.