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Int. J. Mol. Sci. 2007, 8(7), 651-661; doi:10.3390/i8070651

Article

UVB-Protective Effects of Isoflavone Extracts from Soybean Cake in Human Keratinocytes

Han-Sun Chiang ¹ , Wen-Bin Wu ¹ , Jia-You Fang ² , Bing-Huei Chen ³ , Tsai-Hua Kao ³ , Ying-Ting Chen ¹ , Chieh-Chen Huang ⁴  and Chi-Feng Hung ^1,*

¹ School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan ² Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan ³ Department of Nutrition and Food Sciences, Fu-Jen Catholic University, Taipei Hsien, Taiwan ⁴ Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan

* Author to whom correspondence should be addressed.

Received: 14 May 2007; in revised form: 20 June 2007 / Accepted: 28 July 2007 / Published: 11 July 2007

(This article belongs to the Special Issue Phenolics and Polyphenolics)

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Abstract: It has been shown by chromatography that aglycone, glucoside, acetylglucosideand malonylglucoside isoflavone extracts prepared from soybean cake showed betterantioxidant activities than isoflavone standards. Consequently, the aim of this study was toevaluate the protective effects of these isoflavone extracts against ultraviolet B (UVB)-induced keratinocyte damage. Our results demonstrated that these soybean cake isoflavoneextracts could inhibit UVB-induced keratinocyte death. Moreover, they could inhibit UVB-induced intracellular release of hydrogen peroxide (H₂O₂) Furthermore, these isoflavoneextracts differentially inhibited UVB-induced MAPK phosphorylation. The ERK1/2 andp38 phosphorylation was not inhibited by all tested isoflavone extracts, whereas JNKphosphorylation was inhibited by group I to group III isoflavone extracts. Since theseisoflavone extracts are relative stable and easily obtained than the isoflavone standards, wesuggest that soybean cake may be a useful potential source for developing effective skincare agents in against photoaging.

Keywords: isoflavone; keratinocyte; UVB.

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