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Int. J. Mol. Sci. 2007, 8(7), 606-617; doi:10.3390/i8070606

Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA

1
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, 610064, P. R. China
2
Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan, 610064, P. R. China
3
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P. R .China
*
Author to whom correspondence should be addressed.
Received: 6 March 2007 / Revised: 6 June 2007 / Accepted: 14 June 2007 / Published: 4 July 2007
(This article belongs to the Special Issue Nucleic Acid Derivatives in Emerging Technologies)
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Abstract

Two novel macrocyclic polyamine ligands and their dinuclear zinc (II)complexes were synthesized and characterized. Their interaction with plasmid DNA wasstudied by gel electrophoresis and fluorescence quenching experiment. The result showedthat these complexes could bind DNA efficiently under physiological conditions.
Keywords: 1,4,7,10-tetraazacyclododecane (cyclen); zinc (II) complexes; imidazolium; synthesis; DNA protection. 1,4,7,10-tetraazacyclododecane (cyclen); zinc (II) complexes; imidazolium; synthesis; DNA protection.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Huang, J.; Huang, Q.-D.; Zhang, J.; Zhou, L.-H.; Li, Q.-L.; Li, K.; Jiang, N.; Lin, H.-H.; Wu, J.; Yu, X.-Q. Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA. Int. J. Mol. Sci. 2007, 8, 606-617.

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