Next Article in Journal
Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
Next Article in Special Issue
The Differentiation of Rat Oligodendroglial Cells Is Highly Influenced by the Oxygen Tension: In Vitro Model Mimicking Physiologically Normoxic Conditions
Previous Article in Journal
Role of 3-Hydroxy Fatty Acid-Induced Hepatic Lipotoxicity in Acute Fatty Liver of Pregnancy
Previous Article in Special Issue
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(1), 325; doi:10.3390/ijms19010325

Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

1
Department of Medical Chemistry, University of Szeged, H-6720 Szeged, Dóm Square 8, Hungary
2
MTA-SZTE Biomimetic Systems Research Group, University of Szeged, H-6720 Szeged, Dóm Square 8, Hungary
3
Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H-6726 Szeged, Temesvári krt. 62, Hungary
*
Author to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 15 January 2018 / Accepted: 18 January 2018 / Published: 22 January 2018
(This article belongs to the Collection Neuroprotective Strategies)
View Full-Text   |   Download PDF [2232 KB, uploaded 24 January 2018]   |  

Abstract

Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (HD), amyotrophic lateral sclerosis, and prion diseases are all characterized by the accumulation of protein aggregates (amyloids) into inclusions and/or plaques. The ubiquitous presence of amyloids in NDDs suggests the involvement of disturbed protein homeostasis (proteostasis) in the underlying pathomechanisms. This review summarizes specific mechanisms that maintain proteostasis, including molecular chaperons, the ubiquitin-proteasome system (UPS), endoplasmic reticulum associated degradation (ERAD), and different autophagic pathways (chaperon mediated-, micro-, and macro-autophagy). The role of heat shock proteins (Hsps) in cellular quality control and degradation of pathogenic proteins is reviewed. Finally, putative therapeutic strategies for efficient removal of cytotoxic proteins from neurons and design of new therapeutic targets against the progression of NDDs are discussed. View Full-Text
Keywords: neurodegenerative diseases; neuroprotection; endoplasmic reticulum associated degradation; ubiquitin-proteasome system; autophagy; heat shock proteins; Hsp-inducers; autophagy modulating drugs neurodegenerative diseases; neuroprotection; endoplasmic reticulum associated degradation; ubiquitin-proteasome system; autophagy; heat shock proteins; Hsp-inducers; autophagy modulating drugs
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Penke, B.; Bogár, F.; Crul, T.; Sántha, M.; Tóth, M.E.; Vígh, L. Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions. Int. J. Mol. Sci. 2018, 19, 325.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top