Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9
AbstractThe evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining was evaluated using semi-quantitative immunoreactivity (IR) scores and correlated to clinical and pathological data. Different types of galectin expression were compared with respect to disease-free survival (DFS) and overall survival (OS). Gal-8 served as a new positive prognostic factor for the OS and DFS of ovarian cancer patients. Gal-9 expression determined the DFS and OS of ovarian cancer patients in two opposing ways—moderate Gal-9 expression was correlated with a reduced outcome as compared to Gal-9 negative cases, while patients with high Gal-9 expression showed the best outcome. View Full-Text
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Schulz, H.; Kuhn, C.; Hofmann, S.; Mayr, D.; Mahner, S.; Jeschke, U.; Schmoeckel, E. Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. Int. J. Mol. Sci. 2018, 19, 323.
Schulz H, Kuhn C, Hofmann S, Mayr D, Mahner S, Jeschke U, Schmoeckel E. Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. International Journal of Molecular Sciences. 2018; 19(1):323.Chicago/Turabian Style
Schulz, Heiko; Kuhn, Christina; Hofmann, Simone; Mayr, Doris; Mahner, Sven; Jeschke, Udo; Schmoeckel, Elisa. 2018. "Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9." Int. J. Mol. Sci. 19, no. 1: 323.
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