Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression
AbstractThe insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer. View Full-Text
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de-Freitas-Junior, J.C.M.; Andrade-da-Costa, J.; Silva, M.C.; Pinho, S.S. Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression. Int. J. Mol. Sci. 2017, 18, 1921.
de-Freitas-Junior JCM, Andrade-da-Costa J, Silva MC, Pinho SS. Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression. International Journal of Molecular Sciences. 2017; 18(9):1921.Chicago/Turabian Style
de-Freitas-Junior, Julio C.M.; Andrade-da-Costa, Jéssica; Silva, Mariana C.; Pinho, Salomé S. 2017. "Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression." Int. J. Mol. Sci. 18, no. 9: 1921.
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