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Int. J. Mol. Sci. 2017, 18(9), 1927; doi:10.3390/ijms18091927

3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures

Dental Research Institute, School of Dentistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-749, Korea
Department of Periodontics and Oral Medicine, School of Dentistry and Department of Biomedical Engineering, College of Engineering, University of Michigan, 1011 North University Ave., Ann Arbor, MI 48109-1078, USA
Authors to whom correspondence should be addressed.
Received: 21 July 2017 / Revised: 1 September 2017 / Accepted: 4 September 2017 / Published: 8 September 2017
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
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Specific orientations of regenerated ligaments are crucially required for mechanoresponsive properties and various biomechanical adaptations, which are the key interplay to support mineralized tissues. Although various 2D platforms or 3D printing systems can guide cellular activities or aligned organizations, it remains a challenge to develop ligament-guided, 3D architectures with the angular controllability for parallel, oblique or perpendicular orientations of cells required for biomechanical support of organs. Here, we show the use of scaffold design by additive manufacturing for specific topographies or angulated microgroove patterns to control cell orientations such as parallel (0°), oblique (45°) and perpendicular (90°) angulations. These results demonstrate that ligament cells displayed highly predictable and controllable orientations along microgroove patterns on 3D biopolymeric scaffolds. Our findings demonstrate that 3D printed topographical approaches can regulate spatiotemporal cell organizations that offer strong potential for adaptation to complex tissue defects to regenerate ligament-bone complexes. View Full-Text
Keywords: 3D printing; ligament; microgroove patterns; biopolymer; tissue engineering 3D printing; ligament; microgroove patterns; biopolymer; tissue engineering

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, C.H.; Kim, K.-H.; Lee, Y.-M.; Giannobile, W.V.; Seol, Y.-J. 3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures. Int. J. Mol. Sci. 2017, 18, 1927.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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