3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures
AbstractSpecific orientations of regenerated ligaments are crucially required for mechanoresponsive properties and various biomechanical adaptations, which are the key interplay to support mineralized tissues. Although various 2D platforms or 3D printing systems can guide cellular activities or aligned organizations, it remains a challenge to develop ligament-guided, 3D architectures with the angular controllability for parallel, oblique or perpendicular orientations of cells required for biomechanical support of organs. Here, we show the use of scaffold design by additive manufacturing for specific topographies or angulated microgroove patterns to control cell orientations such as parallel (0°), oblique (45°) and perpendicular (90°) angulations. These results demonstrate that ligament cells displayed highly predictable and controllable orientations along microgroove patterns on 3D biopolymeric scaffolds. Our findings demonstrate that 3D printed topographical approaches can regulate spatiotemporal cell organizations that offer strong potential for adaptation to complex tissue defects to regenerate ligament-bone complexes. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 2373 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Park, C.H.; Kim, K.-H.; Lee, Y.-M.; Giannobile, W.V.; Seol, Y.-J. 3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures. Int. J. Mol. Sci. 2017, 18, 1927.
Park CH, Kim K-H, Lee Y-M, Giannobile WV, Seol Y-J. 3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures. International Journal of Molecular Sciences. 2017; 18(9):1927.Chicago/Turabian Style
Park, Chan H.; Kim, Kyoung-Hwa; Lee, Yong-Moo; Giannobile, William V.; Seol, Yang-Jo. 2017. "3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures." Int. J. Mol. Sci. 18, no. 9: 1927.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.