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Int. J. Mol. Sci. 2017, 18(10), 2056; doi:10.3390/ijms18102056

Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children

Child Neurology, Children’s Hospital, University of Eastern Finland and Kuopio University Hospital, P.O. Box 1627, FI-70211 Kuopio, Finland
Received: 22 August 2017 / Revised: 12 September 2017 / Accepted: 20 September 2017 / Published: 26 September 2017
(This article belongs to the Special Issue IGFs in Health and Disease)
View Full-Text   |   Download PDF [273 KB, uploaded 26 September 2017]

Abstract

Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy–hypsarrhythmia–optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD). View Full-Text
Keywords: insulin-like growth factor; pathogenesis; neonates; neurodevelopmental disorders; neurodegeneration; neuroprotection; children insulin-like growth factor; pathogenesis; neonates; neurodevelopmental disorders; neurodegeneration; neuroprotection; children
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Riikonen, R. Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children. Int. J. Mol. Sci. 2017, 18, 2056.

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