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Int. J. Mol. Sci. 2017, 18(8), 1777; doi:10.3390/ijms18081777

Advances in Understanding of Penile Carcinogenesis: The Search for Actionable Targets

1
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
2
Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
3
Department of Urology, Temple University, Philadelphia, PA 19140, USA
4
Department of Biological Sciences, University of Notre Dame, South Bend, IN 46556, USA
*
Author to whom correspondence should be addressed.
Received: 1 August 2017 / Revised: 13 August 2017 / Accepted: 14 August 2017 / Published: 16 August 2017
(This article belongs to the Special Issue Molecular Research on Urology)
View Full-Text   |   Download PDF [781 KB, uploaded 16 August 2017]   |  

Abstract

Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Metastatic PeCa is challenging to treat and often requires multidisciplinary approaches in management. Due to its rarity, molecular understanding of the disease continues to be limited with most studies based on small, single center series. Thus far, it appears PeCa has diverse mechanisms of carcinogenesis affecting similar molecular pathways. In this review, we evaluate the current landscape of the molecular carcinogenesis of PeCa and explore ongoing research on potential actionable targets of therapy. The emergence of anti-epidermal growth factor receptor (EGFR) and other immunotherapeutic strategies may improve outcomes for PeCa patients. View Full-Text
Keywords: penile cancer; molecular carcinogenesis; actionable targets penile cancer; molecular carcinogenesis; actionable targets
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chipollini, J.; Chaing, S.; Azizi, M.; Kidd, L.C.; Kim, P.; Spiess, P.E. Advances in Understanding of Penile Carcinogenesis: The Search for Actionable Targets. Int. J. Mol. Sci. 2017, 18, 1777.

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