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Int. J. Mol. Sci. 2017, 18(8), 1794; doi:10.3390/ijms18081794

Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
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Received: 20 July 2017 / Revised: 10 August 2017 / Accepted: 12 August 2017 / Published: 18 August 2017
(This article belongs to the Special Issue Molecular Research on Urology)
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Abstract

Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poorly responsive to first- and second-line therapeutic options. Recently, a significant amount of research has been devoted to exploring neuroprotective and neuroregenerative approaches to salvage erectile function in patients with CNI. In addition, therapeutic options such as neuregulins, immunophilin ligands, gene therapy, stem cell therapy and novel surgical strategies, have shown benefit in pre-clinical, and limited clinical studies. In the era of personalized medicine, these new therapeutic technologies will be the future of ED treatment and are described in this review. View Full-Text
Keywords: erectile dysfunction; cavernous nerve injury; regenerative medicine; neuroprotection erectile dysfunction; cavernous nerve injury; regenerative medicine; neuroprotection
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Campbell, J.D.; Burnett, A.L. Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury. Int. J. Mol. Sci. 2017, 18, 1794.

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