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Int. J. Mol. Sci. 2017, 18(8), 1721; doi:10.3390/ijms18081721

Teratogenic Effects of Topiramate in a Zebrafish Model

1
Department of Chemistry, Chinese Culture University, No. 55 Huagang Road, Taipei 111, Taiwan
2
Department of Chemistry, Tamkang University, No. 151 Ying-chuan Road, Tamsui, New Taipei City 25137, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 June 2017 / Revised: 20 July 2017 / Accepted: 24 July 2017 / Published: 7 August 2017
(This article belongs to the Section Molecular Toxicology)
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Abstract

Topiramate is commonly used for treating epilepsy in both children and adults. Recent clinical data suggests that administration of topiramate to women during pregnancy increases the risk of oral clefts in their offspring. To better understand the potential effects of topiramate, we dosed adult female zebrafish with topiramate, and investigated the altered morphologies in adult females and their offspring. It showed that topiramate-treated female fish had reduced oocyte maturation, and the survival rates of their offspring were seriously decreased during embryogenesis. In addition, around 23% of offspring displayed cartilage malformation in the craniofacial area, such as loss of ceratobranchial cartilages as well as impaired ceratohyal, Meckel’s cartilage and ethmoid plate development. Moreover, mineralization of ceratohyal, Meckel’s cartilage, and vertebrae were downregulated during bone development. Taken together, we concluded that topiramate impaired oogenesis in the maternal reproductive system, and then caused offspring cartilage malformation or bone dysplasia. View Full-Text
Keywords: topiramate; ceratobranchial defect; teratology; zebrafish topiramate; ceratobranchial defect; teratology; zebrafish
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MDPI and ACS Style

Lai, Y.-H.; Ding, Y.-J.; Moses, D.; Chen, Y.-H. Teratogenic Effects of Topiramate in a Zebrafish Model. Int. J. Mol. Sci. 2017, 18, 1721.

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