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Int. J. Mol. Sci. 2017, 18(8), 1645; doi:10.3390/ijms18081645

Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment

1
Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA
2
Purdue University Center for Cancer Research, West Lafayette, IN 47907, USA
*
Author to whom correspondence should be addressed.
Received: 6 May 2017 / Revised: 19 July 2017 / Accepted: 21 July 2017 / Published: 28 July 2017
(This article belongs to the Special Issue The Mechanism of Action of Food Components in Disease Prevention 2017)
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Abstract

Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and chemopreventive agent. Preclinical studies provide ample evidence that DATS regulates multiple cancer hallmark pathways including cell cycle, apoptosis, angiogenesis, invasion, and metastasis. DATS has been shown to arrest cancer cells at multiple stages of the cell cycle with the G2/M arrest being the most widely reported. Additionally, increased pro-apoptotic capacity as a result of regulating intrinsic and extrinsic apoptotic pathway components has been widely reported following DATS treatment. Invasion, migration, and angiogenesis represent emerging targets of DATS and support its anti-cancer properties. This review summarizes DATS mechanisms of action as an anti-cancer and chemopreventive agent. These studies provide rationale for future investigation into its use as a cancer chemopreventive agent. View Full-Text
Keywords: diallyl trisulfide; Allium; cancer chemoprevention diallyl trisulfide; Allium; cancer chemoprevention
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Puccinelli, M.T.; Stan, S.D. Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment. Int. J. Mol. Sci. 2017, 18, 1645.

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