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Int. J. Mol. Sci. 2017, 18(7), 1598; doi:10.3390/ijms18071598

An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity

1
Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid 28040, Spain
2
Institute of Investigation Hospital 12 Octubre, Madrid 28041, Spain
*
Author to whom correspondence should be addressed.
Received: 26 June 2017 / Revised: 12 July 2017 / Accepted: 19 July 2017 / Published: 24 July 2017
(This article belongs to the Special Issue Immunology of Aging)
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Abstract

The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity. View Full-Text
Keywords: proliferation; cytokine; aging; longevity; leukocytes proliferation; cytokine; aging; longevity; leukocytes
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Martínez de Toda, I.; Vida, C.; De la Fuente, M. An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity. Int. J. Mol. Sci. 2017, 18, 1598.

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