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Int. J. Mol. Sci. 2017, 18(7), 1599; doi:10.3390/ijms18071599

Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia–Reperfusion Injury

Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, China
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Received: 22 June 2017 / Revised: 18 July 2017 / Accepted: 19 July 2017 / Published: 24 July 2017
(This article belongs to the Special Issue Free Radicals and Oxidants in Pathogenesis)
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Abstract

Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia–reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key factors at various stages have not been fully elucidated. Mitochondrial dysfunction is one of the most important mechanisms of CIR. The mitochondrial deacetylase, sirtuin 3 (SIRT3), can inhibit mitochondrial oxidative stress by deacetylation, to maintain mitochondrial stability. Uncoupling protein 2 (UCP2) regulates ATP (Adenosine triphosphate) and reactive oxygen species production by affecting the mitochondrial respiratory chain, which may play a protective role in CIR. Finally, we propose that UCP2 regulates the activity of SIRT3 through sensing the energy level and, in turn, maintaining the mitochondrial steady state, which demonstrates a cytoprotective effect on CIR. View Full-Text
Keywords: uncoupling protein 2 (UCP2); sirtuin 3 (SIRT3); peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α); oxidative stress; cerebral ischemia/reperfusion injury; mitochondria uncoupling protein 2 (UCP2); sirtuin 3 (SIRT3); peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α); oxidative stress; cerebral ischemia/reperfusion injury; mitochondria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Su, J.; Liu, J.; Yan, X.-Y.; Zhang, Y.; Zhang, J.-J.; Zhang, L.-C.; Sun, L.-K. Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia–Reperfusion Injury. Int. J. Mol. Sci. 2017, 18, 1599.

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