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Int. J. Mol. Sci. 2017, 18(8), 1742; doi:10.3390/ijms18081742

Markers of T Cell Senescence in Humans

1,2
and
1,2,3,4,5,*
1
Biology of Aging Program and Immunomonitoring Platform, Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Singapore 138648, Singapore
2
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
3
Department of Microbiology, National University of Singapore, Singapore 117597, Singapore
4
Department of Geriatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
5
Faculty of Sciences, University ElManar, Tunis 1068, Tunisia
*
Author to whom correspondence should be addressed.
Received: 31 May 2017 / Revised: 22 July 2017 / Accepted: 26 July 2017 / Published: 10 August 2017
(This article belongs to the Special Issue Immunology of Aging)
View Full-Text   |   Download PDF [1152 KB, uploaded 11 August 2017]   |  

Abstract

Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers. View Full-Text
Keywords: human aging; immunosenescence; immune system; T cells; senescence; markers; phenotyping human aging; immunosenescence; immune system; T cells; senescence; markers; phenotyping
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xu, W.; Larbi, A. Markers of T Cell Senescence in Humans. Int. J. Mol. Sci. 2017, 18, 1742.

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