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Int. J. Mol. Sci. 2017, 18(7), 1595; doi:10.3390/ijms18071595

Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy

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1
Chinese Academy of Sciences, Institute of Subtropical Agriculture, Key Laboratory of Agroecological Processes in Subtropical Region, Changsha 410125, China
2
National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410125, China
3
Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha 410125, China
4
Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South Central, Ministry of Agriculture, Changsha 410125, China
*
Author to whom correspondence should be addressed.
Received: 20 June 2017 / Revised: 11 July 2017 / Accepted: 19 July 2017 / Published: 24 July 2017
(This article belongs to the Special Issue Free Radicals and Oxidants in Pathogenesis)
View Full-Text   |   Download PDF [1939 KB, uploaded 24 July 2017]   |  

Abstract

During pregnancy, tryptophan (Trp) is required for several purposes, and Trp metabolism varies over time in the mother and fetus. Increased oxidative stress (OS) with high metabolic, energy and oxygen demands during normal pregnancy or in pregnancy-associated disorders has been reported. Taking the antioxidant properties of Trp and its metabolites into consideration, we made four hypotheses. First, the use of Trp and its metabolites is optional based on their antioxidant properties during pregnancy. Second, dynamic Trp metabolism is an accommodation mechanism in response to OS. Third, regulation of Trp metabolism could be used to control/attenuate OS according to variations in Trp metabolism during pregnancy. Fourth, OS-mediated injury could be alleviated by regulation of Trp metabolism in pregnancy-associated disorders. Future studies in normal/abnormal pregnancies and in associated disorders should include measurements of free Trp, total Trp, Trp metabolites, and activities of Trp-degrading enzymes in plasma. Abnormal pregnancies and some associated disorders may be associated with disordered Trp metabolism related to OS. Mounting evidence suggests that the investigation of the use of Trp and its metabolites in pregnancy will be meanful. View Full-Text
Keywords: tryptophan; antioxidant; oxidative stress; pregnancy; tryptophan metabolites tryptophan; antioxidant; oxidative stress; pregnancy; tryptophan metabolites
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MDPI and ACS Style

Xu, K.; Liu, H.; Bai, M.; Gao, J.; Wu, X.; Yin, Y. Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy. Int. J. Mol. Sci. 2017, 18, 1595.

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