miRNAs in Normal and Malignant Hematopoiesis
AbstractLineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18–24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies. View Full-Text
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Kotaki, R.; Koyama-Nasu, R.; Yamakawa, N.; Kotani, A. miRNAs in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2017, 18, 1495.
Kotaki R, Koyama-Nasu R, Yamakawa N, Kotani A. miRNAs in Normal and Malignant Hematopoiesis. International Journal of Molecular Sciences. 2017; 18(7):1495.Chicago/Turabian Style
Kotaki, Ryutaro; Koyama-Nasu, Ryo; Yamakawa, Natsuko; Kotani, Ai. 2017. "miRNAs in Normal and Malignant Hematopoiesis." Int. J. Mol. Sci. 18, no. 7: 1495.
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