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Int. J. Mol. Sci. 2017, 18(7), 1495; doi:10.3390/ijms18071495

miRNAs in Normal and Malignant Hematopoiesis

Department of Hematology and Oncology, Tokai University School of Medicine, Hiratsuka 259-1193, Japan
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Received: 1 May 2017 / Revised: 21 June 2017 / Accepted: 25 June 2017 / Published: 11 July 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
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Abstract

Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18–24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies. View Full-Text
Keywords: miRNA; lymphoma; leukemia; B-cell miRNA; lymphoma; leukemia; B-cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kotaki, R.; Koyama-Nasu, R.; Yamakawa, N.; Kotani, A. miRNAs in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2017, 18, 1495.

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