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Int. J. Mol. Sci. 2017, 18(7), 1510; doi:10.3390/ijms18071510

miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway

1
Graduate School of Peking Union Medical College, NO. 9, Dongdansantiao, Dongcheng District, Beijing 100730, China
2
Department of Biochemistry, Capital Institute of Pediatrics, NO. 2, Yabao Road, Chaoyang District, Beijing 100020, China
*
Author to whom correspondence should be addressed.
Received: 30 June 2017 / Revised: 6 July 2017 / Accepted: 6 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
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Abstract

MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an apparent decreasing trend after induction, and sustained low expression throughout the differentiation of 3T3-L1 cells. miR-206-3p blocked the adipogenic differentiation of 3T3-L1 cells by attenuating c-Met expression; the inhibition effect of miR-206 to the adipogenic differentiation can be counteracted by restoring c-Met expression. In addition, miR-206-3p decreased the phosphorylation of Akt, which is the downstream effector of c-Met in the PI3K/Akt signaling pathway. These data indicate that miR-206-3p inhibits adipocyte adipogenesis through silencing c-Met and subsequently inactivating the PI3K/Akt signaling pathway. View Full-Text
Keywords: miR-206-3p; c-Met; Akt signaling; adipogenesis miR-206-3p; c-Met; Akt signaling; adipogenesis
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MDPI and ACS Style

Tang, R.; Ma, F.; Li, W.; Ouyang, S.; Liu, Z.; Wu, J. miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway. Int. J. Mol. Sci. 2017, 18, 1510.

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