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Int. J. Mol. Sci. 2017, 18(7), 1439; doi:10.3390/ijms18071439

Abnormally Increased Secretion in Olfactory Neuronal Precursors from a Case of Schizophrenia Is Modulated by Melatonin: A Pilot Study

1
Departamento de Neurofisiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101 San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico
2
Laboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101 San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 May 2017 / Revised: 26 June 2017 / Accepted: 29 June 2017 / Published: 13 July 2017
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Abstract

The alterations that underlie the pathophysiology of schizophrenia (SCZ) include the dysregulation of structural and functional properties of neurons. Among these, the secretion of neurotransmitters and hormones, which plays a key role for neuronal communication and development, is altered. Neuronal precursors from the human olfactory epithelium have been recently characterized as a reliable model for studying the etiopathogenesis of neuropsychiatric diseases. Our previous work has shown that melatonin enhances the development of morphological and functional features of cloned olfactory neuronal precursors (ONPs) from a healthy subject. In this work we found that primary cultures of ONPs obtained from a schizophrenic patient display an increased potassium-evoked secretion, when compared with ONPs from an age- and gender-matched healthy control subject (HCS). Secretion was evaluated by FM1-43 fluorescence cumulative changes in response to depolarization. Interestingly, a 12 h-melatonin treatment modulated the abnormally increased secretion in SCZ ONPs and brought it to levels similar to those found in the HCS ONPs. Our results suggest that the actin cytoskeleton might be a target for melatonin effects, since it induces the thickening of actin microfilament bundles. Further research will address the mechanisms by which melatonin modulates neurochemical secretion from ONPs. View Full-Text
Keywords: schizophrenia; secretion/exocytosis; olfactory neuronal precursors; melatonin; actin cytoskeleton; secretory vesicles schizophrenia; secretion/exocytosis; olfactory neuronal precursors; melatonin; actin cytoskeleton; secretory vesicles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cercós, M.G.; Galván-Arrieta, T.; Valdés-Tovar, M.; Solís-Chagoyán, H.; Argueta, J.; Benítez-King, G.; Trueta, C. Abnormally Increased Secretion in Olfactory Neuronal Precursors from a Case of Schizophrenia Is Modulated by Melatonin: A Pilot Study. Int. J. Mol. Sci. 2017, 18, 1439.

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