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Int. J. Mol. Sci. 2017, 18(6), 639; doi:10.3390/ijms18060639

State of Art of Cancer Pharmacogenomics in Latin American Populations

1
Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Quito 170527, Ecuador
2
Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain
3
Instituto de Fisiopatología y Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Centro de Diagnóstico Molecular, MEDgenomica, Buenos Aires 1000-1499, Argentina
4
Unidad de Bioequivalencia y Medicina Personalizada, Facultad de Medicina, Universidad de San Martín de Porres, Lima 12, Peru
5
Laboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology, Faculty of Medicine, University of Chile, Santiago 70111, Chile
*
Author to whom correspondence should be addressed.
Academic Editors: Sabrina Angelini and Gloria Ravegnini
Received: 27 December 2016 / Revised: 7 March 2017 / Accepted: 10 March 2017 / Published: 23 May 2017
(This article belongs to the Special Issue Pharmacogenetics and Personalized Medicine 2016)
View Full-Text   |   Download PDF [1319 KB, uploaded 24 May 2017]   |  

Abstract

Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations. View Full-Text
Keywords: cancer; single nucleotide polymorphism; precision medicine; Latin America; pharmacogenetics; pharmacogenomics cancer; single nucleotide polymorphism; precision medicine; Latin America; pharmacogenetics; pharmacogenomics
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López-Cortés, A.; Guerrero, S.; Redal, M.A.; Alvarado, A.T.; Quiñones, L.A. State of Art of Cancer Pharmacogenomics in Latin American Populations. Int. J. Mol. Sci. 2017, 18, 639.

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