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Int. J. Mol. Sci. 2017, 18(6), 1290; doi:10.3390/ijms18061290

Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review

Faculty of Pharmacy A15, The University of Sydney, Sydney NSW 2006, Australia
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Received: 26 May 2017 / Revised: 12 June 2017 / Accepted: 15 June 2017 / Published: 17 June 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes. It is anticipated that important information, in a comprehensive and concise manner, will be delivered here for better understanding of natural product drug discovery research. View Full-Text
Keywords: propolis; diterpenes; anticancer; antibacterial; Brazilian propolis; Mediterranean propolis; European propolis propolis; diterpenes; anticancer; antibacterial; Brazilian propolis; Mediterranean propolis; European propolis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Aminimoghadamfarouj, N.; Nematollahi, A. Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review. Int. J. Mol. Sci. 2017, 18, 1290.

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