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Int. J. Mol. Sci. 2017, 18(6), 1195; doi:10.3390/ijms18061195

Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling

1
College of Veterinary Medicine, BK21PLUS project, Chonbuk National University, 79 Gobong-ro, Iksan-city, Jeollabuk-do 54596, Korea
2
Sunchang Reserch Institute of Health and Longevity, Ingye-myeon Indeok-ro, Sunchang-gun, Jeollabuk-do 56015, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Alejandro Cifuentes
Received: 21 February 2017 / Revised: 15 May 2017 / Accepted: 17 May 2017 / Published: 5 June 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [8239 KB, uploaded 5 June 2017]   |  

Abstract

Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family. The purpose of this study is to explore the gastroprotective effect of the Aronia melanocarpa hydro-alcoholic extract (AMHAE) against ethanol-induced gastric ulcer in a rat model. Different concentrations (50, 100, and 200 mg/kg) of AMHAE, or 30 mg/kg of omeprazole, significantly inhibited the gastric injury formation. The ethanol-induced ulcer group showed significant increases of malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor (TNF)-α, nuclear factor-kappaB p65 (NF-κB p65), and monocyte chemoattractant protein (MCP)-1, and decreased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), and interleukin (IL)-4. However, AMHAE (200 mg/kg) pretreatment significantly reversed the altered pathophysiological levels of these biomolecules to near normal stages. The gastroprotective activity of AMHAE was abolished by pretreatment with l-NAME, naloxone, capsazepine, and indomethacin, demonstrating the participation of nitric oxide (NO), opioids, TRPV (vanilloid receptor-related transient receptor potential), and prostaglandins in AMHAE-assisted gastroprotection against ethanol-induced gastric injuries. This gastroprotective effect of AMHAE might be due to the downregulation of TNF-α-based NF-κB, MCP-1 signaling and strong antioxidant properties. View Full-Text
Keywords: gastroprotective activity; ethanol-induced gastric ulcer; Aronia melanocarpa; ulcer index gastroprotective activity; ethanol-induced gastric ulcer; Aronia melanocarpa; ulcer index
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Paulrayer, A.; Adithan, A.; Lee, J.H.; Moon, K.H.; Kim, D.G.; Im, S.Y.; Kang, C.-W.; Kim, N.S.; Kim, J.-H. Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling. Int. J. Mol. Sci. 2017, 18, 1195.

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