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Int. J. Mol. Sci. 2017, 18(6), 1181; doi:10.3390/ijms18061181

Qualitative and Quantitative Assessment of Vascular Changes in Diabetic Macular Edema after Dexamethasone Implant Using Optical Coherence Tomography Angiography

1
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University “G. D’Annunzio” Chieti-Pescara, Chieti 66100, Italy
2
Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste 34100, Italy
3
Department of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University “G. D’Annunzio” Chieti-Pescara, Chieti 66100, Italy
4
School of Hygiene and Preventive Medicine, Department of Medicine and Science of Ageing, University “G. D’Annunzio” Chieti-Pescara, Chieti 66100, Italy
5
Ophthalmology Clinic, Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila 67100, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Claudio Bucolo
Received: 15 April 2017 / Revised: 15 May 2017 / Accepted: 30 May 2017 / Published: 2 June 2017
(This article belongs to the Special Issue Retinal Diseases: Bridging Basic and Clinical Research)
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Abstract

The aim of this study was to investigate retinal and choriocapillaris vessel changes in diabetic macular edema (DME) after the intravitreal dexamethasone implant (IDI) using optical coherence tomography angiography (OCTA). Moreover, a comparison between morphological and functional parameters of DME and healthy patients was performed. Twenty-five eyes of 25 type 2 diabetic retinopathy patients complicated by macular edema (DME group) and 25 healthy subjects (control group) were enrolled. Superficial capillary plexus density (SCPD) and deep capillary plexus density (DCPD) in the foveal and parafoveal areas, choricapillary density (CCD) and optic disc vessel density (ODVD) were detected using OCTA at baseline and after 7, 30, 60, 90 and 120 days post injection. Best corrected visual acuity (BCVA), retinal sensitivity, and central retinal thickness (CMT) were also evaluated in both groups of patients. A statistically significant difference between the two groups (DME and controls) was found in terms of functional (MP, p < 0.001 and BCVA, p < 0.001) and morphological (CMT, p < 0.001; SCPD in the parafoveal area, p < 0.001; DCPD in the foveal area, p < 0.05 and parafoveal area, p < 0.001; CCD, p < 0.001) parameters. After the treatment, SCPD and DCPD in the foveal and parafoveal areas did not modify significantly during the follow up. View Full-Text
Keywords: optical coherence tomography angiography; diabetic macular edema; intravitreal dexamethasone implant; diabetic retinopathy optical coherence tomography angiography; diabetic macular edema; intravitreal dexamethasone implant; diabetic retinopathy
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MDPI and ACS Style

Toto, L.; D’Aloisio, R.; Di Nicola, M.; Di Martino, G.; Di Staso, S.; Ciancaglini, M.; Tognetto, D.; Mastropasqua, L. Qualitative and Quantitative Assessment of Vascular Changes in Diabetic Macular Edema after Dexamethasone Implant Using Optical Coherence Tomography Angiography. Int. J. Mol. Sci. 2017, 18, 1181.

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