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Int. J. Mol. Sci. 2017, 18(6), 1143; doi:10.3390/ijms18061143

Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series

1
Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
2
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
3
Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
4
Department of Human Physiology, Flinders University, Adelaide, SA 5001, Australia
*
Author to whom correspondence should be addressed.
Academic Editors: Margaret Fahnestock and Keri Martinowich
Received: 12 April 2017 / Revised: 10 May 2017 / Accepted: 10 May 2017 / Published: 26 May 2017
(This article belongs to the Special Issue Neurotrophic Factors—Historical Perspective and New Directions)
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Abstract

Nerve growth factor (NGF) is a protein whose importance to research and its elucidation of fundamental mechanisms in cell and neurobiology far outstrips its basic physiological roles. It was the first of a broad class of cell regulators, largely acting through autocrine and paracrine interactions which will be described herein. It was of similar significance in establishing the identity and unique roles of neurotrophic factors in the development and maintenance of the peripheral and central nervous systems. Finally, it contributed to many advances in the elaboration of cell surface receptor mechanisms and intracellular cell signaling. As such, it can be considered to be a “molecular Rosetta Stone”. In this brief review, the highlights of these various studies are summarized, particularly as illustrated by their coverage in the 13 NGF international meetings that have been held since 1986. View Full-Text
Keywords: growth factors; neurotrophins; cell signaling; receptors; central nervous system; devleopment growth factors; neurotrophins; cell signaling; receptors; central nervous system; devleopment
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Bradshaw, R.A.; Mobley, W.; Rush, R.A. Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int. J. Mol. Sci. 2017, 18, 1143.

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