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Int. J. Mol. Sci. 2017, 18(6), 1141; doi:10.3390/ijms18061141

Anti-Inflammatory Properties of Brazilian Green Propolis Encapsulated in a γ-Cyclodextrin Complex in Mice Fed a Western-Type Diet

1
Institute of Human Nutrition and Food Science, Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, 24118 Kiel, Germany
2
Institute of Food Chemistry, Technical University Braunschweig, Schleinitzstrasse 20, 38106 Braunschweig, Germany
3
Graduate School of Medicine, Kobe University, 7-5-1, Kusunoki-cho, Chuo-ku, 650-0017 Kobe, Japan
4
CycloChem Bio Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, 650-0047 Kobe, Japan
5
School of Natural System, Kanazawa University, Kakuma-machi, 920-1192 Kanazawa, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Toshio Morikawa
Received: 15 March 2017 / Accepted: 18 May 2017 / Published: 26 May 2017
(This article belongs to the Section Biochemistry and Molecular Biology)
View Full-Text   |   Download PDF [2647 KB, uploaded 26 May 2017]   |  

Abstract

Ageing is often accompanied by chronic inflammation. A fat- and sugar-rich Western-type diet (WTD) may accelerate the ageing phenotype. Cell culture studies have indicated that artepillin C-containing Brazilian green propolis exhibits anti-inflammatory properties. However, little is known regarding its anti-inflammatory potential in mouse liver in vivo. In this study, female C57BL/6NRj wild-type mice were fed a WTD, a WTD supplemented with Brazilian green propolis supercritical extract (GPSE) encapsulated in γ-cyclodextrin (γCD) or a WTD plus γCD for 10 weeks. GPSE-γCD did not affect the food intake, body weight or body composition of the mice. However, mRNA levels of the tumour necrosis factor α were significantly downregulated (p < 0.05) in these mice compared to those in the WTD-fed controls. Furthermore, the gene expression levels of other pro-inflammatory markers, including serum amyloid P, were significantly (p < 0.001) decreased following GPSE-γCD treatment. GPSE-γCD significantly induced hepatic ferritin gene expression (p < 0.01), which may contribute to its anti-inflammatory properties. Conversely, GPSE-γCD did not affect the biomarkers of endogenous antioxidant defence, including catalase, glutathione peroxidase-4, paraoxonase-1, glutamate cysteine ligase and nuclear factor erythroid 2-related factor-2 (Nrf2). Overall, the present data suggest that dietary GPSE-γCD exhibits anti-inflammatory, but not antioxidant activity in mouse liver in vivo. Thus, GPSE-γCD has the potential to serve as a natural hepatoprotective bioactive compound for dietary-mediated strategies against chronic inflammation. View Full-Text
Keywords: Brazilian green propolis; artepillin C; mice; inflammation; antioxidant defence; diet Brazilian green propolis; artepillin C; mice; inflammation; antioxidant defence; diet
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Rimbach, G.; Fischer, A.; Schloesser, A.; Jerz, G.; Ikuta, N.; Ishida, Y.; Matsuzawa, R.; Matsugo, S.; Huebbe, P.; Terao, K. Anti-Inflammatory Properties of Brazilian Green Propolis Encapsulated in a γ-Cyclodextrin Complex in Mice Fed a Western-Type Diet. Int. J. Mol. Sci. 2017, 18, 1141.

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